Intended for healthcare professionals

Letters Surrogate end point scrutiny

A more evidence based approach to the use of surrogate end points in policy making

BMJ 2011; 343 doi: (Published 25 October 2011) Cite this as: BMJ 2011;343:d6498
  1. Oriana Ciani, PhD student1,
  2. Rod S Taylor, professor of health services research1
  1. 1Peninsula Technology Assessment Group (PenTAG), Peninsula College of Medicine and Dentistry, University of Exeter, Exeter EX2 4SG, UK
  1. oriana.ciani{at}

By retracing the history of particular surrogate outcome failures,1 Moynihan dismisses the assessment of surrogate outcomes in future clinical trials and instead recommends collecting only final outcomes such as survival.2 We agree that, when possible, decisions on the adoption and coverage of health technologies …

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