Taking non-aspirin NSAIDs in early pregnancy doubles risk of miscarriage, study shows

The risk of miscarriage among women who took any type and dosage of non-steroidal anti-inflammatory drug (NSAID), excluding aspirin, in early pregnancy is more than double that among pregnant women who did not, concludes a new study published in the journal of the Canadian Medical Association (CMAJ doi:10.1503/cmaj.110454).

The principal investigator, Anick Bérard, professor in the Faculty of Pharmacy at the University of Montreal, said, “We consistently saw that the risk of having a spontaneous abortion was associated with gestational use of diclofenac, naproxen, celecoxib, ibuprofen, and rofecoxib alone or in combination, suggesting a class effect. We did not see a dose-response …