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Letters Paroxetine during pregnancy

Paroxetine is associated with malformation during pregnancy

BMJ 2011; 343 doi: (Published 10 August 2011) Cite this as: BMJ 2011;343:d5060
  1. Derelie Mangin, associate professor1,
  2. David Healy, professor2,
  3. Barbara Mintzes, assistant professor3
  1. 1Department of Public Health and General Practice Christchurch, University of Otago, New Zealand
  2. 2North Wales Department of Psychological Medicine, Cardiff University, UK
  3. 3Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
  1. dee.mangin{at}

In their clinical review of the diagnosis and management of premenstrual disorders O’Brien and colleagues state1: “Obviously, some patients may become pregnant while taking SSRIs [selective serotonin reuptake inhibitors] and these drugs have not been shown to be teratogenic” with a reference to an article reviewing the adverse effects of SSRIs in pregnancy.2 This is incorrect and is inconsistent …

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