Intended for healthcare professionals

Letters Infective endocarditis

NICE v world on endocarditis prophylaxis

BMJ 2011; 342 doi: (Published 14 June 2011) Cite this as: BMJ 2011;342:d3531
  1. John B Chambers, professor of clinical cardiology1,
  2. David Shanson, consultant in infectious diseases2,
  3. Graham Venn, consultant cardiac surgeon1,
  4. John Pepper, professor of cardiac surgery3
  1. 1Cardiothoracic Centre, St Thomas’ Hospital, London SE1 7EH, UK
  2. 2Department of Medical Microbiology, Great Ormond Street Hospital, London, UK
  3. 3Brompton Hospital, London, UK
  1. jboydchambers{at}

Articles defending the National Institute for Health and Clinical Excellence’s (NICE) advocacy of no antibiotic prophylaxis tend to suggest that the contrary position is universal antibiotic prophylaxis.1 But the essential difference between American, European, and Australian guidelines and those from NICE is in advising antibiotics for high risk cardiac patients (those with …

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