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Letters Thrombolysis in elderly people

Authors’ reply

BMJ 2011; 342 doi: (Published 19 January 2011) Cite this as: BMJ 2011;342:d312
  1. Kennedy R Lees, professor of cerebrovascular medicine1,
  2. Nishant K Mishra, doctoral candidate1
  1. 1Acute Stroke Unit and Cerebrovascular Clinic, Western Infirmary, Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G11 6NT, UK
  1. k.r.lees{at}

Our paper details the measures taken to preclude bias and acknowledges potential overestimation of effects,1 but residual caution over design issues should be assuaged by the simple expedient of comparing the treatment effect in elderly against that in young people.2 These controlled data now encompass 2612 very elderly patients who received alteplase plus a similar number of controls.2 3 Intriguing …

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