Intended for healthcare professionals


Genetic link to depression is replicated by two separate research teams

BMJ 2011; 342 doi: (Published 16 May 2011) Cite this as: BMJ 2011;342:d3050
  1. Zosia Kmietowicz
  1. 1London

Two groups of researchers working independently have identified variations in the same region of a chromosome in people with severe depression. Although the association may contribute to only a small proportion of the risk of depression, it is hoped that the finding will help to locate the genes affected in people with depression, enable better understanding of the mechanism underlying the disease, and ultimately lead to more personalised treatments that reflect the wide variation in how depression presents.

Although many previous studies have linked depression to variations on a number of other chromosomes and identified possible genes for depression, it is believed that none of these findings has been replicated, meaning that they could be false. Normally replication is very difficult and can take years to emerge, if …

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