Intended for healthcare professionals

Endgames Statistical Question

Analysis by per protocol

BMJ 2011; 342 doi: (Published 18 April 2011) Cite this as: BMJ 2011;342:d2330
  1. Philip Sedgwick, senior lecturer in medical statistics
  1. 1Section of Medical and Healthcare Education, St George’s, University of London, Tooting, London, UK
  1. p.sedgwick{at}
  • Competing interests: None declared.

A randomised controlled trial evaluated the effectiveness of an integrated care programme in facilitating the return to work for patients with chronic low back pain.1 The programme was a combined patient and workplace directed intervention. Control treatment was the usual care programme. Trial participants were recruited from primary and secondary care if they were aged 18-65 years, had had low back pain for more than 12 weeks, were in paid work, and had been absent or partially absent from work. In total, 66 participants were assigned to integrated care and 68 to usual care.

The primary outcome was length of time off work after randomisation until a fully sustained return to work. The study period was 12 months. Analysis was undertaken according to the principle of intention to treat and compared with those of …

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