For healthcare professionals only


Clinical risk prediction of pre-eclampsia

BMJ 2011; 342 doi: (Published 07 April 2011) Cite this as: BMJ 2011;342:d1863
  1. Laura A Magee, clinical professor of medicine,
  2. Peter von Dadelszen, associate professor of obstetrics and gynaecology
  1. 1University of British Columbia and British Columbia Women’s Hospital and Health Centre, Vancouver, BC, Canada, V6H 3N1
  1. lmagee{at}

A helpful tool, but not reliable enough to replace traditional methods of detection

Pre-eclampsia remains a leading cause of maternal and perinatal mortality and morbidity worldwide.1 In the linked study (doi:10.1136/bmj.d1875), North and colleagues present a predictive model for pre-eclampsia that is based on routine clinical data.2

The study used data from 3529 “healthy” nulliparous women with a singleton pregnancy participating in the Screening for Pregnancy Endpoints (SCOPE) study.3 The SCOPE study is a large international undertaking that makes an important contribution towards assessing potential risk markers, individually and in combination. North and colleagues have identified nine clinical predictors of pre-eclampsia: one protective (miscarriage at ≤10 weeks’ gestation with the same partner) and eight associated with increased risk (younger maternal age, higher mean arterial blood pressure, higher body mass index, family history of pre-eclampsia, family history of coronary heart disease, the woman having a lower birth weight, vaginal bleeding for at least five days during early pregnancy, and duration of sexual relationship six months or less). All can be collected easily in routine clinical practice, and …

View Full Text

Log in

Log in through your institution


* For online subscription