HIV drugs halve infection rate in men who have sex with men, study finds

BMJ 2010; 341 doi: (Published 23 November 2010) Cite this as: BMJ 2010;341:c6737
  1. Bob Roehr
  1. 1Washington, DC

Once a day dosing of a pill containing two standard antiretrovirals offers significant protection against infection with the virus, a large trial has found.

The international pre-exposure prophylaxis initiative trial, published on 23 November in the New England Journal of Medicine (doi:10.1056/NEJMoa1011205), took place in six countries on four continents.

The trial enrolled 2499 high risk men or transgender women who have sex with men, randomising them to receive once a day dosing of either the combination treatment of tenofovir with emtricitabine (marketed as Truvada) or placebo. The analysis was based on a median use of the drug of 1.2 years.

HIV disproportionately affects men who have sex with men, who constitute about half of all infected people in developed countries. In sub-Saharan Africa men who have …

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