HIV drugs halve infection rate in men who have sex with men, study findsBMJ 2010; 341 doi: https://doi.org/10.1136/bmj.c6737 (Published 23 November 2010) Cite this as: BMJ 2010;341:c6737
- Bob Roehr
- 1Washington, DC
Once a day dosing of a pill containing two standard antiretrovirals offers significant protection against infection with the virus, a large trial has found.
The international pre-exposure prophylaxis initiative trial, published on 23 November in the New England Journal of Medicine (doi:10.1056/NEJMoa1011205), took place in six countries on four continents.
The trial enrolled 2499 high risk men or transgender women who have sex with men, randomising them to receive once a day dosing of either the combination treatment of tenofovir with emtricitabine (marketed as Truvada) or placebo. The analysis was based on a median use of the drug of 1.2 years.
HIV disproportionately affects men who have sex with men, who constitute about half of all infected people in developed countries. In sub-Saharan Africa men who have …