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Letters Glucosamine and osteoarthritis

Prescribed regimen is effective

BMJ 2010; 341 doi: (Published 09 November 2010) Cite this as: BMJ 2010;341:c6335
  1. Jean-Yves Reginster, president and chair1,
  2. Roy D Altman, professor of medicine2,
  3. Marc C Hochberg, professor of medicine and epidemiology and public health3
  1. 1Department of Public Health Sciences, University of Liège, 4000 Liège, Belgium
  2. 2University of California, Los Angeles, 1000 Veterans Avenue, Los Angeles, CA 90024, USA
  3. 3University of Maryland School of Medicine, Baltimore, MD 21201, USA
  1. jyreginster{at}

In a network meta-analysis of glucosamine in osteoarthritis, Wandel and colleagues did not separate the three long term trials of prescription glucosamine sulphate from those using over the counter products lacking evidence of efficacy or bioequivalence.1 A Cochrane review confirmed that the only product showing efficacy is prescription glucosamine sulphate 1500 mg once daily.2 3

The authors diluted the efficacy of glucosamine sulphate in knee osteoarthritis …

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