Intended for healthcare professionals

Letters Calcium and heart attacks

Making too much of a weak case

BMJ 2010; 341 doi: (Published 15 September 2010) Cite this as: BMJ 2010;341:c4997
  1. B E Christopher Nordin, professor1,
  2. Robin M Daly, director of research2,
  3. John Horowitz, head of cardiology3,
  4. Andrew V Metcalfe, associate professor4
  1. 1Endocrine and Metabolic Unit, Royal Adelaide Hospital; Discipline of Medicine, University of Adelaide, Adelaide, SA 5005, Australia
  2. 2Department of Medicine, University of Melbourne, Western Hospital, Melbourne, VIC 3011, Australia
  3. 3Queen Elizabeth Hospital, Woodville South, SA 5011
  4. 4Discipline of Statistics, School of Mathematical Sciences, University of Adelaide, Adelaide, SA 5005
  1. christopher.nordin{at}

    The paper by Bolland and colleagues is seriously flawed in many respects, the first being its misleading title.1 It is not a meta-analysis in the usually accepted sense—that is, a review of published trials. Most of the data are unpublished, were obtained by direct request from the relevant authors, and are impossible to investigate independently.

    The review provides some …

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