Intended for healthcare professionals


Non-endoscopic screening for Barrett’s oesophagus

BMJ 2010; 341 doi: (Published 10 September 2010) Cite this as: BMJ 2010;341:c4667
  1. Peter A Bampton, head of luminal gastroenterology and associate professor in gastroenterology
  1. 1Flinders Medical Centre and Flinders University, Bedford Park, SA 5042, Australia
  1. peter.bampton{at}

    Might help identify biomarkers that can predict a higher risk of developing adenocarcinoma

    Barrett’s oesophagus is characterised by the development of columnar line oesophageal mucosa and is thought to be a premalignant condition that increases the risk of adenocarcinoma of the oesophagus 30-40-fold. Adenocarcinoma of the oesophagus has a poor five year survival (0-13%). The incidence has increased from 7.6 to 12.8 per 100 000 men and 4.2 to 5.7 per 100 000 women over the past three decades in England and Wales,1 and from 0.7 to 3.2 per 100 000 in the United States.2 Cohort studies suggest that survival is longer in people with adenocarcinoma detected by surveillance than in those presenting with symptoms, and surveillance is recommended by all major gastroenterology societies, although evidence from randomised controlled trials to support this practice is lacking.3 In the linked study (doi:10.1136/bmj.c4372), Kadri and colleagues assessed whether non-endoscopic screening for Barrett’s oesophagus, using an ingestible oesophageal sampling device (Cytosponge) coupled with immunocytochemisty for trefoil factor 3, was accurate and acceptable to patients. …

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