Giving oxygen in acute myocardial infarction may raise death risk, Cochrane review concludes

BMJ 2010; 340 doi: (Published 16 June 2010) Cite this as: BMJ 2010;340:c3227
  1. Susan Mayor
  1. 1London

    A Cochrane systematic review has found no evidence that the routine practice of giving inhaled oxygen to patients with acute myocardial infarction is beneficial, and it may even increase mortality, it says. Its authors call for a large trial to be carried out urgently to provide a clear answer.

    Oxygen is routinely given to patients with acute myocardial infarction, with clinical guidelines in most countries recommending its use in emergency care. The rationale is that this may improve oxygenation of the ischaemic myocardium and so reduce cardiac pain, infarct size, and consequent morbidity and mortality. However, previous studies have found insufficient evidence to determine whether oxygen had any …

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