Concentration of insulin-like growth factor is linked with breast cancer

BMJ 2010; 340 doi: (Published 18 May 2010) Cite this as: BMJ 2010;340:c2653
  1. Rebecca Wilkins
  1. 1London

    Women with high blood concentrations of insulin-like growth factor 1 (IGF-1) are more likely than those with low concentrations to develop breast cancer, research that is based on evidence from around the world has found.

    Cancer Research UK’s study, led by Oxford University’s Tim Key and published in Lancet Oncology on 17 May (doi:10.1016/S1470-2045(10)70095-4), analysed 17 studies from across 12 countries that together involved nearly 5000 women with breast cancer.

    The normal function of IGF-1 is to stimulate cell division, especially during childhood development.

    The 20% of women with the highest concentration of IGF-1 were found to have a 28% …

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