BMJ 2010; 340 doi: https://doi.org/10.1136/bmj.c2606 (Published 17 May 2010) Cite this as: BMJ 2010;340:c2606

Could Alzheimer’s disease be a cerebral form of glaucoma? A paper in 1994 speculated that high intracranial pressure might increase the risk of developing Alzheimer’s and current research presented in Medical Hypotheses supports this notion (2010;74:973-7 doi:10.1016/j.mehy.2009.12.019). Exposure of tissue in the central nervous system to high pressure is not unique—a similar situation occurs in the intraocular pressure in eyes with glaucoma. The way ganglion cells in the retina die in glaucoma is similar to the death of neuronal cells in Alzheimer’s. The anatomical and functional similarities between the intracranial pressure and intraocular pressure spaces could be the link between Alzheimer’s and glaucoma.

Children with sickle cell disease are living longer, but as they move into adult care, their survival advantage vanishes, and they remain at high risk of early death. The evidence from one large US cohort study suggests that quality of care has improved, with more initial and early visits and preventative interventions for young children. Sepsis is no longer the main cause of death. However, all the recent deaths in …

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