Intended for healthcare professionals

Endgames Statistical Question

Per protocol analysis

BMJ 2010; 340 doi: (Published 07 April 2010) Cite this as: BMJ 2010;340:c1825
  1. Philip Sedgwick, senior lecturer in medical statistics
  1. 1Centre for Medical and Healthcare Education, St George’s, University of London, London
  1. p.sedgwick{at}

    A randomised controlled trial investigated the effects of a low energy liquid diet on moderate and severe obstructive sleep apnoea in obese men.1 Men in the control group adhered to their usual diet. A total of 63 men were recruited, of which 30 were allocated to the intervention group and 33 to the control group. Two of the men allocated to the control group were dissatisfied with their allocation, having wanted the intervention, and subsequently withdrew from the trial.

    The primary end point was the apnoea-hypopnoea index, the …

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