Intended for healthcare professionals



BMJ 2010; 340 doi: (Published 29 March 2010) Cite this as: BMJ 2010;340:c1727

A unique collaboration known as EAGLE (Early Genetics and Lifecourse Epidemiology)—a consortium of 20 different large scale birth and paediatric cohorts with genetic data relating to phenotyping and genome wide screening—offers the opportunity for identifying genetic loci associated with several health outcomes from early fetal life to young adulthood. The collaborators are seeking to increase the power of the project by inviting others to join them in the venture. The database is updated regularly at

The risk of uterine rupture after previous caesarean section is difficult to quantify but a Norwegian study found that compared with elective prelabour caesarean section, the odds of rupture increased for emergency prelabour caesarean section, spontaneous labour, and induced labour. The odds were also increased for women older than 40 years (v under 30), non-Western women, and gestational age over 41 weeks (v 37-40 weeks). Trial of labour carried greater risk and worse outcome of rupture than elective repeated caesarean section, although absolute risks were low (BJOG 2010; doi:10.1111/j.1471-0528.2010.02533.x)

A therapeutic pathway currently being explored for Alzheimer’s disease may actually make things worse (Proceedings of the National Academy of Sciences 2010; published online 22 March, …

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