Letters
Metformin and lactic acidosis
Metformin: framed again?
BMJ 2009; 339 doi: https://doi.org/10.1136/bmj.b5570 (Published 23 December 2009) Cite this as: BMJ 2009;339:b5570
- David J Preiss, clinical research fellow1,
- Naveed Sattar, professor of metabolic medicine1
- 1BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow G12 8TA
- d.preiss{at}clinmed.gla.ac.uk
Fitzgerald and colleagues show that metformin treatment should be avoided in acute renal failure,1 but their focus on metformin associated lactic acidosis is misplaced.
Metformin has long been suggested as a cause of lactic acidosis in published case reports, but evidence from large cohorts and meta-analyses of controlled trials remains conspicuously absent.2 Metformin is often …
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