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BMJ 2009; 339 doi: (Published 02 December 2009) Cite this as: BMJ 2009;339:b5093

Do methylprednisolone injections into the eardrum cure tinnitus? In a randomised placebo controlled single blind study, 70 adults with subjective tinnitus of cochlear origin were randomly assigned to receive intratympanic injections of either methylprednisolone or saline. Data from 59 patients were available for analysis. Both groups reported an improvement, but there were no significant differences between the two groups, and side effects—a burning sensation and bitter taste—were more commonly reported in the methylprednisolone group (Journal of Laryngology and Otology 2009;123:1221-5, doi:10.1017/S0022215109990685).

An American study suggested an association between high levels of dietary selenium and diabetes and hyperlipidaemia. Now a UK study reports on a population of more than a thousand adults with lower selenium levels. Higher plasma selenium levels were associated with increased total and non-high density lipoprotein, but not with high density lipoprotein. Causality of the potential effects of selenium on cardiovascular risk needs to be assessed with randomised and mechanistic evidence, but once again dietary …

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