Intended for healthcare professionals


The case for population-wide salt reduction gets stronger

BMJ 2009; 339 doi: (Published 25 November 2009) Cite this as: BMJ 2009;339:b4980
  1. Lawrence J Appel, professor of medicine, epidemiology, and international health (human nutrition)
  1. 1Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, 2024 East Monument Street, Suite 2-618, Baltimore, MD 21205-2223, USA
  1. lappel{at}

    A meta-analysis of cohort studies confirms the benefits for preventing stroke and heart disease

    Excess intake of salt (sodium chloride) has an important and probably predominant role in the pathogenesis of raised blood pressure. The evidence is indisputable—on average, as salt intake increases, blood pressure increases. Animal studies, migration studies, ecological studies, longitudinal observational studies, clinical trials, and meta-analyses of trials have confirmed this association.1 The importance of this association cannot be overstated—blood pressure is an aetiologically relevant and modifiable cardiovascular risk factor, which has guided policy makers for decades.

    Worldwide, raised blood pressure accounts for around 62% of strokes and 49% of coronary heart disease events.2 Large scale trials and meta-analyses of trials have conclusively shown that several treatments that reduce blood pressure prevent stroke and coronary heart disease.3 This compelling evidence has led numerous authoritative bodies to conclude that salt reduction, through its effects on blood pressure, should also prevent stroke and coronary heart disease. Direct evidence to support calls for salt reduction has been limited, however, so the linked meta-analysis of cohort studies by Strazzullo and colleagues (doi:10.1136/bmj.b4567) is a useful and welcome addition to the medical literature.4

    The …

    View Full Text

    Log in

    Log in through your institution


    * For online subscription