The highs and lows of policy based evidence
BMJ 2009; 339 doi: https://doi.org/10.1136/bmj.b4564 (Published 04 November 2009) Cite this as: BMJ 2009;339:b4564All rapid responses
Rapid responses are electronic comments to the editor. They enable our users to debate issues raised in articles published on bmj.com. A rapid response is first posted online. If you need the URL (web address) of an individual response, simply click on the response headline and copy the URL from the browser window. A proportion of responses will, after editing, be published online and in the print journal as letters, which are indexed in PubMed. Rapid responses are not indexed in PubMed and they are not journal articles. The BMJ reserves the right to remove responses which are being wilfully misrepresented as published articles or when it is brought to our attention that a response spreads misinformation.
From March 2022, the word limit for rapid responses will be 600 words not including references and author details. We will no longer post responses that exceed this limit.
The word limit for letters selected from posted responses remains 300 words.
Editor
Colquhoun leaves the best point to last - we need more doctors in the
house! In fact we need more Independent MPs and ideally they would be of a
background and mindset and sufficient in number to impose the sorts of
changes in so many areas of national life that we all seek.
We can have evidence based policy, comprehensive public services,
meaningful political discourse, a rational position in the community of
nations, a vibrant cohesive civic society and so much else besides if...
We can have these things if we get elected but in order to do that we
have to stick our heads over the parapet and join in. The world is run by
those who turn up.
There are no adequate excuses for failing to act, given the
extraordinary concatenation of circumstances in our country. Don't just
froth and fulminate - stand for parliament. I am.
Yours sincerely
Steven Ford
Competing interests:
I am standing as an Independent candidate at the next general election - health policy is amongst my key topics.
Competing interests: No competing interests
Well said David. Your credibility leaps up hugely in my
estimation.. Shooting the messenger is indeed an ancient crime. The
message then quickly gets lost, whilst we are diverted into the nature of
committee decision-making.
Science depends crucially on the ability to challenge long-accepted
paradigms, by producing and testing alternative hypotheses, and openly and
robustly debating their explanatory power over the 'Flat-Earthist' , or
'Ex-Cathedra' policy-makers in power.
First they duck-stool the heretics, then shoot the cranks, then they
sack the Nutts. After that they'll come for you and me, David. Before
long there will be no independent thinkers left..
And SCIENCE will be the loser.
Competing interests:
None declared
Competing interests: No competing interests
Mark Struthers poses an interesting question. Evan Harris called for
an inquiry nearly six years ago but what we actually have is an endlessly
prolonged disciplinary hearing which will only have limited conclusions,
and does not bear on questions of science. So, when do we get the inquiry
into autism, bowel disease, and the real concerns of the parents that
Harris called for?
Of course, we obviously cannot discuss the science if you put the
chief witnesses on trial.
Competing interests:
Autism parent
Competing interests: No competing interests
We should indeed be thankful to Professor Nutt for forcing
the government's "policy based evidence" approach into
public discourse, but the problem is broader and more
insidious than the debate on Drugs Policy.
It is fairly clear that Alan Johnson's attitude on drugs is
based on a desire to have policies appealing to a group I
will call the Daily Mail Reading Voter (DMRV). This is a
significant group that New Labour recognized it would have
to win over if it was going to get elected and reelected.
DMRVs are thought to like policies that are "tough" on
crime, drugs and public disorder.
The DMRV is particularly attracted to logically simple
policies. Making drugs illegal and telling people they are
bad should reduce consumption. Restrictive licensing hours
and higher prices should cut down alcohol abuse. Stiffer
sentences should reduce crime. To the DMRV it is obvious
that these policies will work.
The trouble with the real world is that it doesn't always
behave in a way that matches the DMRV's simple logic. While
there are large grey areas, some ideas are empirically
testable and the experiments are often not pleasing to the
DMRV. We know, for example, that cannabis consumption did
not boom when cannabis was downgraded to a class c drug; we
know that alcohol consumption in england declined when
licensing hours were relaxed; both effects the opposite of
the expected effect in DMRV logic.
Johnson's argument that government must send out strong
signals about the evils of ecstasy and cannabis to prevent
their wider use is a clear appeal to the DMRV and clearly
contrary to the evidence.
Luckily for science Nutt was never a government employee and
could talk about the evidence in public without worrying too
much about the affect on the DMRV's attitudes.
But the government does employ a lot of scientists and it
pays a lot of scientists to do studies. Unfortunately these
people are not as free or fearless as Nutt. There are two
major and insidious consequences for scientific honesty.
First the government can commission original research to
back up its policy (there isn't much incentive to actually
test policy as this might lead to results displeasing to the
DMRV).
Second, the scientists themselves may volunteer research
proposals that are likely to attract funding, rather than
those which genuinely test the prevailing policy. (or
perhaps they don't like to do work that just ends up being
suppressed. The US government managed to stop the Word
Health Organization publishing a major study that concluded
that cocaine wasn't that bad. See
http://www.tdpf.org.uk/WHOleaked.pdf That is a lot of futile
work for the contributors.)
These two effects together produce masses of poor quality
science with weak conclusions. An example would be british
policy on alcohol. The Chief Medical Officer (a government
employee) recently tried to outdo the Home Office in his
appeal to the DMRV by suggesting all sorts of new
restrictions and pricing measures on alcohol. Some of the
research he based his position on was research he had
commissioned. But it wasn't exactly starting from an
unbiased position and trying to genuinely test policy
alternatives. In fact most of the literature on the topic
starts with a point of view and seeks to prove it usually
using the weakest methodology possible. So despite the fact
that alcohol consumption has declined since the relaxation
of licensing in england, the CMO can still assert that
studies show restrictions on supply is the most important
constraint on the level of consumption.
Another example would be the extremely dodgy use of road
accident statistics to bolster the Home Office policy about
the use of speed cameras.
The large volume of poorly designed and conducted studies
(in many areas where science could impact policy) which
appear to exist for the sole purpose of reinforcing
preconceived opinions are bad for science. Spin and truth
are uncomfortable bedfellows whether the spin comes from
scientists trying to please their paymasters or governments
trying to suppress unwelcome facts.
Competing interests:
None declared
Competing interests: No competing interests
What’s so special about Professor Nutt? What is so special about
Nutt’s science?
Why is this Professor accorded such a high level of supportive
outrage from the likes of David Colquhoun and ‘doctor in the House’, Evan
Harris, Liberal Democrat member of the House’s science and technology
select committee?
Where is the outrage at the punishment meted out to Professors Walker
-Smith and Murch at the GMC? [1] Why is Nutt’s scientific advice
considered so much more trustworthy than Dr Andrew Wakefield’s, peer
reviewed, Lancet published science?
Dr Evan Harris, MP for Oxford West and Abingdon, in a 2004 ‘Times
Online’ article, stated,
“The children with autism and/or bowel disease have real needs, their
parents real concerns.” [2]
And where will we now find the scientists to investigate the reality
of these parental concerns and these children’s needs?
Tragically, the muddy relations between corporate scientists, House
physicians and this government are a quagmire into which honest science
has been lost. Pity the children.
[1] Wakefield tells GMC he was motivated by concern for autistic
children. Owen Dyer. BMJ 2008 336: 738.
http://www.bmj.com/cgi/content/full/336/7647/738
[2] Comment: Dr Evan Harris MP: For the children's sake, we need an
inquiry. Times Online, February 22, 2004.
http://www.timesonline.co.uk/tol/news/uk/health/article1027825.ece
Competing interests:
None declared
Competing interests: No competing interests
Independent?
David Colquhoun writes [1]:
"In the House of Commons Mr Johnson said, "I asked Professor Nutt to
resign as my principal drugs adviser, not because of the work of the
council but because of his failure to recognise that, as chair of ACMD,
his role is to advise rather than to criticise government policy on
drugs." But Mr Johnson had it wrong. Nutt, unlike, for example, the chief
scientific adviser, is not a civil servant. He is an academic. It is his
job to be independent. He is paid nothing for all his hard work on the
ACMD. He has a day job to do as well. It is his job to criticise whatever
he thinks it right to criticise."
In this post Blairite era it may seem strange to point out that Civil
Servants are paid to be independent. On the other hand academics are
expected as things are to seek out the direct patronage of industry. In
the case of David Nutt he states in a article [2]:
"The author has received grants, speaker’s honoraria or consulting
fees from all of the pharmaceutical companies that have developed and
marketed the antidepressants discussed in Cipriani et al. (2009)."
The article reproduces a chart from Cipriani et al which includes in
alphabetical order (I have added the names of associated manufacturers):
Bupropion (GlaxoSmithKline), Citalopram (Forest Laboratories),
Duloxetine (Eli Lilly)
Escitalopram (Lundbeck and Forest Laboratories),Fluoxetine (Eli Lilly),
Fluvoxamine (Solvay), Milnacipran (Cypress Bioscience), Mirtazapine
(Organon International), Paroxetine (GlaxoSmithKline)),Reboxetine (Pfizer)
andVenlafaxine (Wyeth)
In his controversial lecture (Eve Saville Lecture, for Centre of
Crime and Justice Studies at King's College, London', as recalled by
Colquhoun, Nutt spoke favourably of the safety of the recreational drugs
cannabis and ecstasy:
"This furore arose simply because Nutt said that cannabis was less
dangerous than tobacco and alcohol (true) and that more people were killed
and brain damaged from riding accidents than from ecstasy (also true)."
But it should also be pointed out that the use of these drugs,
particularly cannabis, has been linked with depression. For instance, the
Royal College of Psychiatry website tells us [3]:
"A study following 1600 Australian school-children, aged 14 to 15 for
seven years, found that while children who use cannabis regularly have a
significantly higher risk of depression, the opposite was not the case -
children who already suffered from depression were not more likely than
anyone else to use cannabis. However, adolescents who used cannabis daily
were five times more likely to develop depression and anxiety in later
life."
Another relevant question might be, in the event of these
recreational drugs ever being legalised, who might manufacture them for
the mass market?
[1] David Colquhoun, 'The highs and lows of policy based evidence',
BMJ 4 November 2009 http://www.bmj.com/cgi/content/full/339/nov04_1/b4564
[2] David J Nutt, 'Prescribing anti-depressants post Cipriani et al'
Journal Psychopharmacology 2009,
http://jop.sagepub.com/cgi/reprint/23/8/865
[3] Royal College of Psychiatrists, 'Cannabis and mental health',
http://www.rcpsych.ac.uk/mentalhealthinformation/mentalhealthproblems/al...
Competing interests:
Autistic son - distrust of pharmaceutical companies
Competing interests: No competing interests