Letters SSRIs and congenital defects

Women should give informed consent before starting SSRIs

BMJ 2009; 339 doi: https://doi.org/10.1136/bmj.b4292 (Published 21 October 2009) Cite this as: BMJ 2009;339:b4292
  1. Derelie Mangin, associate professor and director1
  1. 1Primary Care Research Unit, Department of Public Health and General Practice, University of Otago, Christchurch, New Zealand
  1. dee.mangin{at}otago.ac.nz

    In Pedersen and colleagues’ study of selective serotonin reuptake inhibitors (SSRIs) in pregnancy, the hazards were clearest for citalopram and sertraline.1 However, a meta-analysis of all epidemiologically robust studies of paroxetine in the first trimester of pregnancy conclusively shows increased prevalence of both cardiac malformations (odds ratio 1.46, 95% confidence interval 1.17 to 1.82) and total malformations (1.24, 1.08 to 1.43).2

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