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Mefloquine has more adverse effects than other drugs for malaria prophylaxis

BMJ 2009; 339 doi: (Published 13 October 2009) Cite this as: BMJ 2009;339:b4167
  1. Lynn Eaton
  1. 1London

    Researchers for the Cochrane Collaboration have found that mefloquine (Lariam) has more adverse effects than the two main alternatives for antimalaria prophylaxis.

    They looked at prophylactic regimens for visitors to countries where Plasmodium falciparum has developed resistance to chloroquine (Cochrane Database of Systematic Reviews 2009;(4):CD006491, doi:10.1002/14651858.CD006491.pub2). Their review looked at the efficacy, safety, and tolerability of three regimens: atovaquone-proguanil (Malarone), doxycycline, and mefloquine.

    On safety, the authors said that the main problem …

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