Intended for healthcare professionals

Letters A/H1N1 flu

Time for case-control studies of NSAIDs and oseltamivir

BMJ 2009; 339 doi: (Published 28 July 2009) Cite this as: BMJ 2009;339:b3048
  1. Andrew Herxheimer, emeritus fellow, UK Cochrane Centre1,
  2. Mike Clarke, director2,
  3. Ralph Edwards, director3,
  4. Tom Jefferson, coordinator4,
  5. Yoon Loke, lecturer in clinical pharmacology5
  1. 1London N3 2NL
  2. 2UK Cochrane Centre, Oxford OX2 7LG
  3. 3Uppsala Monitoring Centre, Box 1051, SE-753 20 Uppsala, Sweden
  4. 4Cochrane Vaccines Field, Via Adige 28a, Anguillara Sabazia, 00061 Rome, Italy
  5. 5University of East Anglia, Norwich NR4 7TJ
  1. a.herxheimer{at}

    Hama highlights our ignorance about the harmful effects of oseltamivir (Tamiflu) and the non-steroidal anti-inflammatory drugs (NSAIDs) commonly used in flu.1 Shimazu suggests that aspirin enhanced virulence in the 1918 epidemic,2 and, as Hama notes, the effects of NSAIDs should be studied in Mexico now.3

    We need these data to decide in what circumstances these drugs are worth …

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