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Commentary: Condition is often overlooked

BMJ 2009; 338 doi: (Published 09 March 2009) Cite this as: BMJ 2009;338:b799
  1. Gerhard J Molderings, associate professor of pharmacology and toxicology
  1. 1Institute of Human Genetics, University Hospital of Bonn, D-53111 Bonn, Germany
  1. molderings{at}

    This report of hypotensive shock as the initial sign of systemic mastocytosis brings attention to an important but underestimated disease. Although systemic mast cell activation syndrome, a variant form of systemic mastocytosis, is probably common in daily practice (for example, it seems to be linked to certain forms of irritable bowel syndrome1), this differential diagnosis is seldom considered. As in the …

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