Intended for healthcare professionals

Letters Drug prevention of hypertension

Assumptions and extrapolation

BMJ 2009; 338 doi: (Published 29 June 2009) Cite this as: BMJ 2009;338:b2600
  1. Sripal Bangalore1,
  2. Franz H Messerli2
  1. 1Division of Cardiology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02445, USA
  2. 2St Luke’s Roosevelt Hospital and Columbia University College of Physicians and Surgeons, New York, NY, USA
  1. sbangalore{at}

    Law and colleagues’ conclusion, that blood pressure should be lowered in everyone over a certain age, rather than measured in everyone and treated in some, is derived from 147 disparate trials.1 The trials have varying inclusion/exclusion criteria, and were conducted in patients aged 34-84, with follow-up of 0.5-8.4 years, and in those with hypertension, after myocardial infarction, with coronary artery disease without myocardial infarction, and with heart failure. …

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