The laureate, the worm, and RNAi
BMJ 2008; 336 doi: https://doi.org/10.1136/sbmj.0801019 (Published 01 January 2008) Cite this as: BMJ 2008;336:0801019
- Ajit Goenka, resident in training1,
- Hrishikesh Kulkarni, medical student2
- 1Department of Radiology, All India Institute of Medical Sciences, New Delhi, India
- 2Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Mumbai, India
What is RNAi?
It is where double stranded RNA inhibits the expression of genes with complementary nucleotide sequences. This phenomenon is proving to be an extraordinary research tool. The realisation that RNAi is a normal means of genetic regulation has opened up a fascinating yet hitherto inconceivable vista in the field of developmental gene regulation. Moreover, RNAi offers tremendous prospects for understanding and manipulating the cellular basis of human diseases.
Did you foresee winning the Nobel prize?
Not really. At first we thought the process of RNAi interesting and we talked about it a lot. But when we found that the process has been conserved across the species we realised that we had hit on something important. We published a …
Log in
Log in using your username and password
Log in through your institution
Subscribe from £184 *
Subscribe and get access to all BMJ articles, and much more.
* For online subscription
Access this article for 1 day for:
£50 / $60/ €56 (excludes VAT)
You can download a PDF version for your personal record.