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Hippisley-Cox et al evaluate risk factors for cardiovascular disease
(1). Apart from statins which the authors exclude in the article, certain
drugs known to increase such risk e.g. oral contraceptives, COX-2
selective inhibitor, could be prescribed during the study. I was wondering
if the authors are aware that the participants still used such drugs while
they perform this cohort study.
1. Hippisley-Cox J, Coupland C, Vinogradova Y, Robson J, Minhas R,
Sheikh A, et al.
Predicting cardiovascular risk in England and Wales: prospective
derivation and validation of QRISK2. BMJ 2008; 336: a332.