Intended for healthcare professionals

Letters Very tight glucose control

May be high risk, low benefit

BMJ 2008; 336 doi: (Published 27 March 2008) Cite this as: BMJ 2008;336:683
  1. John S Yudkin, emeritus professor of medicine, University College London
  1. 1London N7 0AG
  1. j.yudkin{at}

    The problems with a glucocentric approach to managing patients with type 2 diabetes1 2 3 can be seen using data from the UKPDS.4 In the 10 years of follow-up of newly diagnosed patients with a mean age of 53, macrovascular events (myocardial infarction and stroke) were five times more common than serious microvascular events (blindness in one eye and renal failure) but, unlike these, were not significantly reduced by intensive glucose lowering. Moreover the observational data from …

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