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Letters Moving beyond depression

How full is the glass?

BMJ 2008; 336 doi: (Published 20 March 2008) Cite this as: BMJ 2008;336:629
  1. Irving Kirsch, professor of psychology,
  2. Blair T Johnson, professor of psychology
  1. 1University of Hull, Hull HU6 7RX
  2. 2Department of Psychology and Center for Health, Intervention, and Prevention, University of Connecticut, Storrs, Connecticut, USA
  1. I.Kirsch{at}

Instead of speculating about our differing methods as the source of our differing conclusions, Turner and Rosenthal instead focused on our adoption of UK’s National Institute for Health and Clinical Excellence (NICE) criteria for clinical significance. NICE adopted Cohen’s definition of a “medium” effect size (0.5) for clinical significance.1 2 Cohen intended that a medium effect size represent an effect of a size likely to …

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