Intended for healthcare professionals

  1. Research
  2. Empirical evidence of...
  3. Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study
Research

Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study

BMJ 2008; 336 doi: https://doi.org/10.1136/bmj.39465.451748.AD (Published 13 March 2008) Cite this as: BMJ 2008;336:601

Related articles

See more

Cited by...

  • Management of plantar heel pain: a best practice guide informed by a systematic review, expert clinical reasoning and patient values
  • Quality of reporting and risk of bias: a review of randomised trials in occupational health
  • Association of study design features and treatment effects in trials of chronic medical conditions: a meta-epidemiological study
  • Blinding in randomised clinical trials of psychological interventions: a retrospective study of published trial reports
  • Heterogeneity of outcomes for intraoperative music interventions: a scoping review and evidence map
  • Retinal implantation of electronic vision prostheses to treat retinitis pigmentosa: A systematic review
  • STEPFORWARD study: a randomised controlled feasibility trial of a self-aligning prosthetic ankle-foot for older patients with vascular-related amputations
  • Comparison of different mobile health applications for intervention in children and adolescent with overweight: a protocol for systematic review with meta-analysis and trial sequential analysis
  • NEMESIS: Noninferiority, Individual-Patient Metaanalysis of Selective Internal Radiation Therapy with 90Y Resin Microspheres Versus Sorafenib in Advanced Hepatocellular Carcinoma
  • Psychotherapy versus treatment as usual and other control interventions in children and adolescents with overweight and obesity: a protocol for systematic review with meta-analysis and Trial Sequential Analysis
  • Effects of adding ivabradine to usual care in patients with angina pectoris: a systematic review of randomised clinical trials with meta-analysis and Trial Sequential Analysis
  • Ethiopian medicinal plants used for their anti-inflammatory, wound healing or anti-infective activities: protocol for systematic literature review and meta-analysis
  • Acupuncture for acute non-specific low back pain: a randomised, controlled, multicentre intervention study in general practice--the Acuback study
  • Longterm Effect on Leisure Time Physical Activity Level in Individuals with Axial Spondyloarthritis: Secondary Analysis of a Randomized Controlled Trial
  • Should antidepressants be used for major depressive disorder?
  • Identifying the 'incredible! Part 2: Spot the difference - a rigorous risk of bias assessment can alter the main findings of a systematic review
  • Identifying the 'incredible! Part 1: assessing the risk of bias in outcomes included in systematic reviews
  • Effects of adding adjunctive hyperbaric oxygen therapy to standard wound care for diabetic foot ulcers: a protocol for a systematic review with meta-analysis and trial sequential analysis
  • TIDieR checklist evaluation of clinical trial intervention reporting for recent FDA-approved anticancer medications
  • High intensity exercise for 3 months reduces disease activity in axial spondyloarthritis (axSpA): a multicentre randomised trial of 100 patients
  • Fools gold? Why blinded trials are not always best
  • Concussed athletes walk slower than non-concussed athletes during cognitive-motor dual-task assessments but not during single-task assessments 2 months after sports concussion: a systematic review and meta-analysis using individual participant data
  • Occupational therapy for people with dementia and their family carers provided at home: a systematic review and meta-analysis
  • Fever control interventions versus placebo, sham or no intervention in adults: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis
  • Cannabinoids versus placebo or no intervention for pain: protocol for a systematic review with meta-analysis and trial sequential analysis
  • Design characteristics, risk of bias, and reporting of randomised controlled trials supporting approvals of cancer drugs by European Medicines Agency, 2014-16: cross sectional analysis
  • Omega-3, omega-6, and total dietary polyunsaturated fat for prevention and treatment of type 2 diabetes mellitus: systematic review and meta-analysis of randomised controlled trials
  • Creation of a database to assess effects of omega-3, omega-6 and total polyunsaturated fats on health: methodology for a set of systematic reviews
  • Risk of bias assessment of randomised controlled trials referenced in the 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care: a cross-sectional review
  • Sexual rehabilitation for cardiac patients with erectile dysfunction: a randomised clinical trial
  • Empirical evidence of the impact of study characteristics on the performance of prediction models: a meta-epidemiological study
  • Methodological advantages and disadvantages of parallel and crossover randomised clinical trials on methylphenidate for attention deficit hyperactivity disorder: a systematic review and meta-analyses
  • Which treatment is most effective for patients with patellofemoral pain? A protocol for a living systematic review including network meta-analysis
  • Effect of vitamin D supplementation on serum 25-hydroxyvitamin D concentration in children and adolescents: a systematic review and meta-analysis protocol
  • Study protocol for a single-centre, prospective, non-blinded, randomised, 12-month, parallel-group superiority study to compare the efficacy of pharmacist intervention versus usual care for elderly patients hospitalised in orthopaedic wards
  • Validation of Exercise Capacity as a Surrogate Endpoint in Exercise-Based Rehabilitation for Heart Failure: A Meta-Analysis of Randomized Controlled Trials
  • Core Outcome Sets
  • Standards and Methodological Rigor in Pulmonary Arterial Hypertension Preclinical and Translational Research
  • Electroacupuncture plus standard of care for managing refractory functional dyspepsia: protocol of a pragmatic trial with economic evaluation
  • Preparing for what the reporting checklists will not tell you: the PREPARE Trial guide for planning clinical research to avoid research waste
  • Influence of allocation concealment and intention-to-treat analysis on treatment effects of physical therapy interventions in low back pain randomised controlled trials: a protocol of a meta-epidemiological study
  • Validity of studies suggesting postsurgical chemotherapy for resectable gastric cancer: critical appraisal of randomised trials
  • CMV and BKPyV Infections in Renal Transplant Recipients Receiving an mTOR Inhibitor-Based Regimen Versus a CNI-Based Regimen: A Systematic Review and Meta-Analysis of Randomized, Controlled Trials
  • The effect of blinding on estimates of mortality in randomised clinical trials of intensive care interventions: protocol for a systematic review and meta-analysis
  • Long-term effect of smartphone-delivered Interval Walking Training on physical activity in patients with type 2 diabetes: protocol for a parallel group single-blinded randomised controlled trial
  • Effect of telemedicine on glycated hemoglobin in diabetes: a systematic review and meta-analysis of randomized trials
  • SheppHeartCABG trial--comprehensive early rehabilitation after coronary artery bypass grafting: a protocol for a randomised clinical trial
  • Effect of characteristics of women on attendance in blind and non-blind randomised trials: analysis of recruitment data from the EPHT Trial
  • Ankle Injury Prevention Programs for Soccer Athletes Are Protective: A Level-I Meta-Analysis
  • Electroacupuncture and splinting versus splinting alone to treat carpal tunnel syndrome: a randomized controlled trial
  • Effect of antenatal education in small classes versus standard auditorium-based lectures on use of pain relief during labour and of obstetric interventions: results from the randomised NEWBORN trial
  • Feasibility of surgical randomised controlled trials with a placebo arm: a systematic review
  • Metformin versus placebo in combination with insulin analogues in patients with type 2 diabetes mellitus--the randomised, blinded Copenhagen Insulin and Metformin Therapy (CIMT) trial
  • Effects of biphasic, basal-bolus or basal insulin analogue treatments on carotid intima-media thickness in patients with type 2 diabetes mellitus: the randomised Copenhagen Insulin and Metformin Therapy (CIMT) trial
  • Professional medical writing support and the quality of randomised controlled trial reporting: a cross-sectional study
  • Methylphenidate for attention-deficit/hyperactivity disorder in children and adolescents: Cochrane systematic review with meta-analyses and trial sequential analyses of randomised clinical trials
  • Simulation-based multiprofessional obstetric anaesthesia training conducted in situ versus off-site leads to similar individual and team outcomes: a randomised educational trial
  • Replication and contradiction of highly cited research papers in psychiatry: 10-year follow-up
  • What is the influence of randomisation sequence generation and allocation concealment on treatment effects of physical therapy trials? A meta-epidemiological study
  • Interpreting Effectiveness Evidence in Pain: Short Tour of Contemporary Issues
  • Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation
  • Transcatheter Versus Surgical Aortic Valve Replacement in Patients With Severe Aortic Valve Stenosis: 1-Year Results From the All-Comers NOTION Randomized Clinical Trial
  • A multistudy analysis investigating systematic differences in cardiovascular trial results between Europe and Asia
  • Avoidable waste of research related to inadequate methods in clinical trials
  • Pain Control After Simultaneous Bilateral Total Knee Arthroplasty: A Randomized Controlled Trial Comparing Periarticular Injection and Epidural Analgesia
  • Labour induction with prostaglandins: a systematic review and network meta-analysis
  • How do systematic reviews incorporate risk of bias assessments into the synthesis of evidence? A methodological study
  • Clinical effects of blood donor characteristics in transfusion recipients: protocol of a framework to study the blood donor-recipient continuum
  • Cerebral near infrared spectroscopy oximetry in extremely preterm infants: phase II randomised clinical trial
  • Efficacy of cognitive bias modification interventions in anxiety and depression: meta-analysis
  • Impact of Spin in the Abstracts of Articles Reporting Results of Randomized Controlled Trials in the Field of Cancer: The SPIIN Randomized Controlled Trial
  • Introduction to the GRADE Approach for Guideline Development: Considerations for Physical Therapist Practice
  • Assessing bias in osteoarthritis trials included in Cochrane reviews: protocol for a meta-epidemiological study
  • Industry sponsorship bias in research findings: a network meta-analysis of LDL cholesterol reduction in randomised trials of statins
  • Interpreting trial results following use of different intention-to-treat approaches for preventing attrition bias: a meta-epidemiological study protocol
  • Sulfonylurea versus metformin monotherapy in patients with type 2 diabetes: a Cochrane systematic review and meta-analysis of randomized clinical trials and trial sequential analysis
  • Identifying Items to Assess Methodological Quality in Physical Therapy Trials: A Factor Analysis
Back to top