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Heart failure associated with thiazolidinediones doesn't reduce survival

BMJ 2007; 335 doi: (Published 04 October 2007) Cite this as: BMJ 2007;335:692

A meta-analysis of seven randomised trials has confirmed that rosiglitazone and pioglitazone increase the risk of heart failure in patients with type 2 diabetes (relative risk 1.72, 95% CI 1.21 to 2.42). Fluid retention is the most likely cause, say the authors. …

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