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Letters Familial hypercholesterolaemia

Cascade testing is tried and tested and cost effective

BMJ 2007; 335 doi: https://doi.org/10.1136/bmj.39353.483160.BE (Published 04 October 2007) Cite this as: BMJ 2007;335:683
  1. Gaye S Hadfield, project coordinator, FH cascade testing audit, London IDEAS Genetics Knowledge Park,
  2. Steve E Humphries, BHF professor of cardiovascular genetics
  1. Department of Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College Medical School, London WC1E 6JJ
  1. rmhaseh{at}ucl.ac.uk

Wald et al suggest that screening children for high cholesterol at the time of immunisation, and then testing the parents of affected children, is an effective screening method for familial hypercholesterolaemia.1 However, their paper does not address acceptability or cost effectiveness.

Earlier data from our group showed that universal screening was much less cost effective than cascade testing (family …

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