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Zoledronic acid seems to reduce risk of repeat breaks and death after hip fracture

BMJ 2007; 335 doi: https://doi.org/10.1136/bmj.39343.363600.DB (Published 20 September 2007) Cite this as: BMJ 2007;335:584
  1. Janice Hopkins Tanne
  1. New York

Patients who had undergone surgical repair of hip fracture after a minor fall and who were then given an annual intravenous infusion of zoledronic acid were less likely to have a new vertebral fracture, to have a new non-vertebral fracture, or to die, a new study has found.

The international, double blind, placebo controlled study was released early by the New England Journal of Medicine (doi: 10.1056/NEJMoa074941). The trial was sponsored by Novartis, the manufacturer of the drug, which is marketed as Reclast in the United States and Aclasta in the United Kingdom.

Just over a third of patients aged over 50 who have had a hip fracture are likely to die within two years, write the authors of an accompanying editorial (doi: 10.1056/NEJMe078192), and …

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