MinervaBMJ 2007; 335 doi: https://doi.org/10.1136/bmj.39324.576076.471 (Published 06 September 2007) Cite this as: BMJ 2007;335:520
Evidence is emerging that the outcome for patients with subarachnoid haemorrhage may be poorer if they carry the APOE4 allele. In a meta-analysis of eight observational studies involving almost 700 patients, E4 carriers were more likely to have a negative outcome (death, dependency, or severe cognitive impairment) and delayed ischaemia. The apoE protein has neurotrophic and antioxidant functions (Neurology 2007;69:766-75 doi: 10.1212/01.wnl.0000267640.03300.6b).
A systematic review of human papillomavirus (HPV) infection and disease in women reports that for women aged 15-25 who were not previously infected with vaccine-type HPV strains, prophylactic vaccination seems to be highly effective in preventing HPV infection and precancerous cervical disease. The proof will be in the pudding, however, when data on a reduction—or otherwise—in the incidence of cervical cancer finally filter through (CMAJ 2007;177:469-79 doi: 10.1503/cmaj.070948).
Could your hospital accommodate the four huge “Acts …