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Be careful with claims that sex modifies genetic risk of disease

BMJ 2007; 335 doi: (Published 06 September 2007) Cite this as: BMJ 2007;335:473

Experience from observational studies and randomised trials teaches us that sex was often misinterpreted as a modifying factor in the risk of disease or response to treatment. For example, on the basis of one underpowered subgroup analysis, we believed for more than a decade that …

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