Letters eGFR and chronic kidney disease

Time to move forward

BMJ 2007; 335 doi: https://doi.org/10.1136/bmj.39273.574479.BE (Published 19 July 2007) Cite this as: BMJ 2007;335:111
  1. C R V Tomson, past chair, Joint Specialty Committee on Renal Medicine of the Renal Association and the Royal College of Physicians1,
  2. E J Lamb, consultant clinical scientist2,
  3. K Griffith, general practitioner3,
  4. D O'Donoghue, national clinical director of kidney care4,
  5. J Feehally, immediate past president, Renal Association5
  1. 1Renal Medicine, Southmead Hospital, Bristol BS10 5NB
  2. 2Clinical Biochemistry, East Kent Hospitals NHS Trust, Kent and Canterbury Hospital, Canterbury CT1 3NG
  3. 3University Health Centre, York University, York YO10 5DD
  4. 4Department of Nephrology, Salford Royal Hospital NHS Trust, Hope Hospital, Salford M6 8HD
  5. 5John Walls Renal Unit, Leicester General Hospital, Leicester LE5 4 PW
  1. edmund.lamb{at}ekht.nhs.uk

    Giles and Fitzmaurice's arguments are designed to persuade BMJ readers that reporting estimated glomerular filtration rate (eGFR) has introduced a screening programme by the back door, will pressurise specialist services, and cause unnecessary anxiety and harm to patients in terms of getting life insurance and receiving inappropriate treatment.1

    The marked increase in referrals of patients with newly diagnosed chronic kidney disease is likely to be temporary due to referral of patients with prevalent disease. UK guidelines ensure that only patients who will receive added value from a specialist opinion are referred2: most can safely and more efficiently be managed in primary care.3 Most patients diagnosed as having chronic kidney disease as a result of eGFR reporting are older, few of whom will take out new life insurance. Angiotensin converting enzyme inhibitors are indicated only in the presence of hypertension (in the quality and outcomes framework (QOF)), in keeping with current NICE guidance.

    Reporting eGFR has improved the clinical interpretation of an established test (serum creatinine).4 An important aim was to reduce the morbidity and mortality associated with late referral to nephrology services of patients with advanced disease.5 The indications for testing serum creatinine concentration have not been changed by eGFR reporting.

    The simplified MDRD (modification of diet in renal disease) equation does not provide a perfect estimate of glomerular filtration rate. Improved assay precision, specificity, and standardisation will help. Currently, harmonisation through the United Kingdom National External Quality Assessment Scheme achieves between-laboratory agreement (coefficient of variation) of around 6% at rates around 60 ml/min/1.73 m2. As the authors acknowledge, the equation is useful to identify stage 3-5 disease, as required by the QOF.


    • Competing interests: None declared.


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