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The evidence on gene mutations in hereditary diffuse gastric cancer is accumulating

BMJ 2007; 334 doi: (Published 14 June 2007) Cite this as: BMJ 2007;334:1244

Hereditary diffuse gastric cancer is an autosomal dominant syndrome of cancer susceptibility. It is caused by germline mutations in the epithelial cadherin (CDH1) gene and is characterised by a high risk for early onset diffuse gastric cancer or lobular breast cancer. The ability to detect CDH1 mutations and thereby identify the syndrome might …

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