Intended for healthcare professionals


Methadone tolerance testing in drug misusers

BMJ 2006; 333 doi: (Published 30 November 2006) Cite this as: BMJ 2006;333:1172

Beyond the edge of safety

  1. Deborah A Zador, consultant physician in addictions1,
  2. Michael Farrell, reader in addiction psychiatry2
  1. 1South London and Maudsley Foundation Trust, London SE5 8RS
  2. 2National Addiction Centre, Institute of Psychiatry, London SE5 8AF

The model of methadone tolerance testing Bakker and Fazey describe is not the solution to this problem.1 They make the assumption that low mean maintenance doses of methadone are a consequence of low starting doses, which are separate issues. The model of induction into methadone treatment recommended in the national clinical guidelines for the management of drug dependence allows for the attainment of adequate optimised maintenance doses. …

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