Comparison of academic performance of twins and singletons in adolescence: follow-up study
BMJ 2006; 333 doi: https://doi.org/10.1136/bmj.38959.650903.7C (Published 23 November 2006) Cite this as: BMJ 2006;333:1095
- Kaare Christensen, professor1,
- Inge Petersen, mathematician1,
- Axel Skytthe, associate professor1,
- Anne Maria Herskind, paediatrician2,
- Matt McGue, professor3,
- Paul Bingley, associate professor4
- 1Danish Twin Registry, Institute of Public Health, University of Southern Denmark
- 2Paediatric Department, Odense University Hospital, Denmark
- 3Department of Psychology, University of Minnesota, USA
- 4Department of Economics, Aarhus School of Business, Denmark
- Correspondence to: K Christensen, Epidemiology, Institute of Health Sciences, University of Southern Denmark, DK-5000 Odense C, Denmark kchristensen{at}health.sdu.dk
- Accepted 23 August 2006
Abstract
Objectives To determine whether twins in recent cohorts show similar academic performance in adolescence to singletons and to test the effect of birth weight on academic performance in twins and singletons.
Design Follow-up study.
Setting Denmark.
Participants All twins (n=3411) and a 5% random sample of singletons (n=7796) born in Denmark during 1986-8.
Main outcome measures Test scores in ninth grade (age 15 or 16), birth weight, gestational age at birth, parents' age, and parents' education.
Results Ninth grade test scores were normally distributed, with almost identical mean and standard deviations for twins and singletons (8.02 v 8.02 and 1.05 v 1.06) despite the twins weighing on average 908 g (95% confidence interval 886 to 930 g) less than the singletons at birth. Controlling for birth weight, gestational age at birth, age at test, and parents' age and education confirmed the similarity of test scores for twins and singletons (difference 0.04, 95% confidence interval −0.03 to 0.10). A significant, positive association between test score and birth weight was observed in both twins and singletons, but the size of the effect was small: 0.06-0.12 standard deviations for every kilogram increase in birth weight.
Conclusions Although older cohorts of twins have been found to have lower mean IQ scores than singletons, twins in recent Danish cohorts show similar academic performance in adolescence to that of singletons. Birth weight has a minimal effect on academic performance in recent cohorts; for twins this effect is best judged relative to what is a normal birth weight for twins and not for singletons.
Introduction
Infertility treatment has doubled the twinning rate in many Western countries to about 2% of births.1 The resulting increased incidence of twins with low birth weight has substantially attenuated decreasing trends in infant mortality.2 Children of extremely low birth weight have considerable long term health and educational needs,3 and twins compared with singletons are about four times more likely to have cerebral palsy4 and are at increased risk of other congenital malformations.5 Even within its normal range, birth weight is positively associated with IQ in children,6 and large scale studies on twins from the mid-20th century show that they score four or five IQ points lower than singletons.7 8 Although newer and smaller studies have questioned this result,9 a recent study concluded that twins born in the 1950s continue to be cognitively disadvantaged compared with singletons.10 None the less, it remains unclear whether an intellectual disadvantage characterises twins in recent birth cohorts, and, if it does exist, whether it is due to a small group of severely affected twins or a shift in the whole distribution of scores for twins towards lower performance. We compared the performance of twins and singletons and the effect of birth weight on academic performance, using nationwide registers of academic performance in ninth graders born in Denmark during 1986-8.
Methods
The Danish civil registration system identifies individuals by unique social security numbers, which can be linked through Statistics Denmark to several thematically organised population databases, or registers. We used information from three registers: the Danish demographic database, which includes information on parents' identities, deaths, migrations, adoptions, and education11; the national hospital discharge register, which includes information on overnight hospital stays for non-psychiatric illnesses12; and the register of compulsory school completion assessments and test scores compiled by the Ministry of Education from school reports.13
The Danish twin registry is a population based register comprising more than 65 000 twin pairs born in Denmark since 1870,14 including all twins born since 1973 as identified through the medical birth registry. Zygosity of same sexed twin pairs has been classified by means of four standard questions, a method with less than 5% misclassification.15 We did not have information on whether the twins were born as a result of assisted conception, but in recent Danish cohorts the risk of neurological sequelae is similar in assisted and naturally conceived twins.16
Danish students in ninth grade (age 15 or 16) are required to complete a general test of academic achievement, which is scored on a scale of 0-13, with average performance rated as 8. The tests cover major domains of academic achievement, including Danish and foreign languages, mathematics, hard science, and social science. These test scores are supplemented by teacher ratings, also on a 0-13 point scale. Reporting of test scores and teacher evaluations is a legal requirement for all schools except special schools for those with learning disabilities. Some private schools do not test, and a small proportion of children in public schools choose not to take the test. We used the average test score for each child and the average of the teacher evaluations completed through ninth grade, as well as test scores for single topics—namely, mathematics and Danish. The test scores were available for the years 2002-4 corresponding to the 1986-8 birth cohorts. The present study is based on all twins and a 5% random sample of singletons born in Denmark during 1986-8. The mean (SD) age at test was 16.0 (0.3) years, for both twins and singletons.
To correct for the correlated nature of the twin data we used the Stata “cluster” option (release 9) based on generalised estimating equations.17
Results
A total of 3652 twin individuals were live born in Denmark during 1986-8, and a 5% random sample of all liveborn singletons in each of these three years yielded 8280 additional individuals. The study base included those who survived to 1 January 2003 and had not emigrated. Mortality in this period was significantly higher among twins than among singletons: 2.7% v 1.1% (95% confidence interval of the difference 1.0% to 2.1%). The excess in twin mortality was limited to the period from birth to 28 days (table 1⇓). More singletons than twins emigrated (4.8% v 3.9%), therefore 93.4% of the twins (n=3411) and 94.2% of the singletons (n=7796) constituted the study base for all subsequent analyses.
Characteristics of twins and singletons born in Denmark during 1986-8. Values are numbers (percentages) unless stated otherwise
During their first year, twins spent more days in hospital than singletons: 16.0 v 6.6 days (95% confidence interval of difference 8.9 to 9.9 days), whereas only small differences were shown for hospital stays from age 1 to 14 years (table 1⇑). The percentage of twins and singletons spending more than two months in hospital during their lifetime was the same (0.7%).
The birth weight and gestational age of twins was significantly lower than that of singletons: 2541 g v 3449 g (mean difference 908 g, 95% confidence interval 886 to 930 g) and 37.0 v 39.7 weeks (95% confidence interval of the difference 2.7 to 2.8 weeks). Consistent with the increased prevalence of dizygotic twinning with maternal age, mothers of twins were significantly older than those of singletons (29.0 v 27.8 years), and a similar pattern was observed in fathers (31.9 v 30.8). The educational level of mothers and fathers was similar for twins and singletons.
Academic performance
Twins and singletons showed almost identical academic performance (figure⇓).
Distribution of ninth grade mean test scores for Danish twins (n=2866) and a 5% random sample (n=6575) of Danish singletons, born 1986-8
Further multivariate analyses confirmed that twins have similar academic performance to singletons, even after controlling for sex, age at test, birth weight (in grams or centiles), gestational age, and parents' age and education. Overall, the results and pattern of the teachers' evaluations as well as the topic specific tests were similar to that for the overall average score—that is, no differences were found between twins and singletons except that twins did slightly better in mathematics than singletons (difference 0.13, 95% confidence interval 0.03 to 0.23).
Twins and singletons with missing test scores
The same proportion of twins and singletons (84%) had a test score: a proportion similar to previous Danish studies.18 Similar proportions of complete test scores for twins and singletons were found in mathematics, Danish, and English.
Health and social indicators for children with and without test scores (table 2⇓) showed minimal differences that were similar for twins and singletons: individuals without a test score spent more days in hospital and had lower birth weight, younger mothers, and parents of a lower mean educational level. The percentage with birth weights less than 1500 g was higher among twins without a test score than with (9.7% v 3.5%), suggesting that extremely low birth weight is associated with non-completion of the ninth grade test. A similar pattern was seen in singletons: 1.4% with a test score and 0.3% without a test score. The percentage of test takers is lower for the 1988 cohort than for the earlier cohorts because some from this cohort had not yet advanced to ninth grade at the time test data were obtained but again the pattern was the same for twins and singletons.
Basic descriptive characteristics of twins and singletons born in Denmark during 1986-8 stratified for presence of ninth grade test score. Values are numbers (percentages) unless stated otherwise
Birth weight
Birth weight had a significant but modest effect on test scores (test performance increased 6% of a standard deviation per kilogram increase in birth weight for singletons and 12% for twins). The significant but small influence of birth weight is confirmed in trend analyses19 and in intrapair analysis, where regression of differences in test score on differences in birth weight within twin pairs shows a difference of one sixth of a standard deviation in test performance per kilogram difference in birth weight. In 1256 pairs of twins with different birth weights (mean difference 309 g), the mean test score was 8.05 for the lighter twin at birth and 8.08 for the heavier twin at birth—a difference of only 3% of a standard deviation. In the 102 pairs where the twins had identical birth weight, the mean test score was 7.99.
Recent results3 suggest that children of extremely low birth weight might be especially at risk for several adverse health outcomes and functional limitations. The strongest evidence for an influence of birth weight on later functioning is the over-representation of children of extremely low birth weight in the 15% of the birth cohorts that did not have a test score in the register.
The failure to find twin-singleton differences in light of the observed, albeit modest, effects of birth weight on test scores may seem anomalous. Table 3⇓ gives mean test performance as a function of birth weight centile separately for twins and singletons. Twins and singletons in the same birthweight centile scored virtually identically, suggesting that relative rather than absolute birth weight is most prognostic.
Mean test scores for birthweight centiles for twins and singletons born in Denmark during 1986-8
Single twins
The 43 twins with a deceased cotwin scored significantly lower than the 2823 twins with a living cotwin: mean (SD) 7.69 (1.20) v 8.03 (1.05); P=0.04.
Discussion
A large national sample of Danish adolescent twins and singletons showed similar performance in the ninth grade test. Birth weight had a minimal effect on performance except for twins of very low birth weight, who were more likely not to have a ninth grade test score. This suggests that a minority of twins—and among them many twins of very low birth weight—have severe physical or cognitive problems whereas most twins perform cognitively similar to singletons.
Our findings run counter to the consistent finding of poorer IQ performance among twins in studies of older cohorts and in particular to findings from a recently published study.10 Although the latter study was based on cohorts born in the 1950s, it was interpreted as showing that twins continue to be at a cognitive disadvantage, possibly because of shorter gestation or impaired foetal growth. Our study questions the validity of this generalisation to recent cohorts of twins.
We interpret our findings as indicating that improvements in obstetric and paediatric practices over the past 50 years have largely ameliorated the cognitive disadvantage identified in twins by earlier research,7 8 10 despite more twins of extremely low birth weight now surviving the first year of life. It is possible that our findings differ from those of earlier research because of country specific factors or differences in measurement. Our research is based on measures of academic achievement rather than IQ. These differences are not likely to be a major factor in accounting for the differences in findings. A recent review20 found that the correlation between IQ and standardised achievement tests is high (average 0.70 to 0.74). The correlation between IQ and national achievement tests, such as the test used here, seem almost this high.21 The high correlation between the two types of assessments suggests that they would produce similar results. In any case, assessments of achievement have a pragmatic advantage over measures of IQ as parents are likely to be more interested in how their twins will do in school than in how they will do in a test of intelligence.
The strength of the study is that it is nationwide, large, and register based, and the important covariates, such as parents' education, were available for almost all participants. The expected associations with covariates, such as a strong correlation between test scores and parents' education, were observed in our sample, suggesting that the quality of the data is high. The major weakness of the study is that we had no information on why test data were missing for about 15% of the population. Missing data can arise because children are too mentally or physically handicapped to participate in a test, and because some schools do not report test scores. None the less, the equal representation of twins and non-twins in the study (84% had scores identified in both groups) makes bias from this source unlikely.
Record et al7 showed that the four or five IQ point disadvantage found in twins from cohorts born in the 1950s did not exist among the subgroup of twins who lost their cotwin early in life, suggesting that social competition may be the cause of the twin disadvantage. We found the opposite pattern in the current sample—namely, that twins with a deceased cotwin scored significantly lower on the academic tests than twins with a living cotwin.
Our study indicates that twins and singletons of extremely low birth weight have lower academic achievement in adolescence than children of average birth weight, and we were able to retrieve reported associations between birth weight and school achievement, although the size of the effect was modest. When we analysed birth weight as centiles separately for twins and singletons, we found no meaningful differences in test scores between twins and singletons in any centile stratum.22 The shift in distribution of birth weight for twins therefore seems to have no effect on cognition in recent twin cohorts. This finding also suggests that the association of birth weight with academic achievement may not be causal, at least within the range of birth weights studied here—that is, a birth weight of 2500 g is associated with mild cognitive deficits in singletons, where it corresponds to the 10th centile, but no cognitive deficits in twins, where it approximately equals the median score.
What is already known on this topic
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In older cohorts twins have mean IQ scores considerably lower than singletons
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Previous studies show a positive association between birth weight and IQ in children
What this study adds
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Twins in recent cohorts have school performance in adolescence similar to singletons
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Birth weight has a minimal effect on school performance in recent cohorts and for twins this is best judged relative to what is a normal birth weight for twins not singletons
Footnotes
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This is version 2 of the paper. In the first version the wording of the results section for participants with missing test scores was incorrect. It should have said that “The percentage with birth weights less than 1500 g was higher among twins without [not with] a test score than with [not without].”
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Contributors: KC initiated the study, obtained funding, supervised the analyses, and was mainly responsible for writing the manuscript. He is guarantor. PB and IP helped develop the protocol, were responsible for creating and analysing the dataset, and helped write the manuscript. MMcG, AMH, and AS assisted with the protocol design, analysis, and writing of the manuscript.
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Funding: University of Southern Denmark.
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Competing interests: None declared.
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Ethical approval: This study was approved by the Danish Data Protection Agency (case No 2000-54-0047).