A meta-analysis of the diagnostic performance of the direct agglutination test and rK39 dipstick for visceral leishmaniasis
BMJ 2006; 333 doi: https://doi.org/10.1136/bmj.38917.503056.7C (Published 05 October 2006) Cite this as: BMJ 2006;333:723
Data supplement
Table A QUADAS tool [As supplied by authors]
Item
Yes
No
Unclear
1. Was the spectrum of patients representative of the patients who will receive the test in practice?
( )
( )
( )
2. Were selection criteria clearly described?
( )
( )
( )
3. Is the reference standard likely to correctly classify the target condition?
( )
( )
( )
4. Is the time period between reference standard and index test short enough to be reasonably sure that the target condition did not change between the two tests?
( )
( )
( )
5. Did the whole sample or a random selection of the sample, receive verification using a reference standard of diagnosis?
( )
( )
( )
6. Did patients receive the same reference standard regardless of the index test results?
( )
( )
( )
7. Was the reference standard independent of the index test (i.e. the index test did not form part of the reference standard)?
( )
( )
( )
8. Was the execution of the index test described in sufficient detail to permit replication of the test?
( )
( )
( )
9. Was the execution of the reference standard described in sufficient detail to permit its replication?
( )
( )
( )
10. Were the index test results interpreted without knowledge of the results of the reference standard?
( )
( )
( )
11. Were the reference standard results interpreted without knowledge of the results of the index test?
( )
( )
( )
12. Were the same clinical data available when tests results were interpreted as would be available when the test is used in practice?
( )
( )
( )
13. Were uninterpretable/intermediate test results reported?
( )
( )
( )
14. Were withdrawals from the study explained?
( )
( )
( )
Table B QUADAS results of the 13 studies evaluating rK39 dipsticks included in the meta-analysis
Studies
Reference
QUADAS items
Total score*
1
2
3
4
5
6
7
8
9
10
11
12
13
14
Goswami et al, 2003
w15
No
Yes
U
U
No
Yes
Yes
Yes
No
Yes
Yes
n.a.
No
No
7
Chappuis et al, 2003
w16
Yes
Yes
Yes
Yes
Yes
Yes
Yes
Yes
Yes
U
Yes
n.a.
U
Yes
12
Sundar et al, 2002
w17
No
Yes
Yes
Yes
No
Yes
Yes
Yes
Yes
Yes
Yes
n.a.
U
No
9.5
Bern et al, 2000
w18
No
No
Yes
U
No
Yes
Yes
Yes
Yes
U
Yes
n.a.
U
No
7.5
Sundar et al, 1998
w19
Yes
Yes
Yes
Yes
No
No
Yes
Yes
Yes
Yes
U
n.a.
U
No
9
Zijltra et al, 2001
w20
No
Yes
Yes
Yes
No
Yes
Yes
Yes
No
U
Yes
n.a.
Yes
No
8.5
Schallig et al, 2002
w21
No
Yes
U
U
No
Yes
Yes
Yes
No
U
Yes
n.a.
U
No
7
Brandonisio et al, 2002
w22
No
Yes
Yes
Yes
No
Yes
Yes
Yes
No
U
Yes
n.a.
U
No
8
Carvalho et al, 2003
w23
No
Yes
Yes
Yes
No
Yes
Yes
Yes
Yes
Yes
Yes
n.a.
U
No
9.5
Sarker et al, 2003
w24
No
Yes
Yes
Yes
No
Yes
Yes
No
Yes
U
Yes
n.a.
U
No
8
Boelaert et al, 2004
w25
Yes
Yes
Yes
Yes
Yes
Yes
U
Yes
Yes
Yes
Yes
n.a.
U
Yes
12
Veeken et al, 2003
w26
No
Yes
Yes
Yes
U
Yes
Yes
No
No
U
U
n.a.
No
No
6.5
Iqbal et al, 2002
w27
No
No
Yes
Yes
No
No
Yes
Yes
Yes
U
No
n.a.
No
No
5.5
U, unclear; n.a., not assessed
*Reply to items: "yes" = 1; "unclear" = 1/2; "no" or "n.a" = 0; the QUADAS score was obtained by adding up the scores of the 14 items.
Table C QUADAS results of the 30 studies evaluating the DAT included in the meta-analysis
Studies
Reference
QUADAS items
Total score
1
2
3
4
5
6
7
8
9
10
11
12
13
14
Zijltra et al, 1992
w1
No
Yes
Yes
Yes
Yes
No
Yes
Yes
Yes
U
No
n.a.
No
No
7.5
Harith et al, 1987
w2
No
Yes
Yes
Yes
No
Yes
Yes
Yes
No
No
Yes
n.a.
No
No
7
Harith et al, 1986
w3
No
Yes
Yes
Yes
No
Yes
Yes
Yes
No
No
Yes
n.a.
No
No
7
Boelaert et al, 1999
w4
No
Yes
Yes
Yes
No
Yes
Yes
Yes
Yes
U
Yes
n.a.
Yes
Yes
10.5
Abdallah et al, 2004
w5
No
No
Yes
Yes
No
Yes
Yes
Yes
Yes
U
Yes
n.a.
No
No
7.5
Lito et al, 2002
w6
No
No
Yes
Yes
No
Yes
Yes
No
No
U
Yes
n.a.
No
No
5.5
Agarwal et al, 1996
w7
No
No
Yes
U
No
Yes
Yes
Yes
No
U
Yes
n.a.
No
No
6
Oskam et al, 1999
w8
No
Yes
Yes
Yes
No
Yes
Yes
Yes
No
U
Yes
n.a.
No
No
7.5
Garcez et al, 1996
w9
No
Yes
U
Yes
No
Yes
Yes
Yes
No
U
Yes
n.a.
No
No
7
Nyakundi et al, 1994
w10
U
U
Yes
Yes
Yes
No
No
No
Yes
Yes
No
n.a.
No
No
6
Singla et al, 1993
w11
No
Yes
U
Yes
No
Yes
Yes
Yes
No
U
Yes
n.a.
No
No
7
Zijlstra et al, 1991
w12
Yes
Yes
Yes
Yes
Yes
U
Yes
Yes
No
U
No
n.a.
No
No
8
Andrade et al, 1989
w13
No
No
U
Yes
No
Yes
Yes
Yes
No
U
Yes
n.a.
No
No
6
Abdel-Hameed et al, 1989
w14
No
Yes
Yes
Yes
No
Yes
Yes
No
U
U
Yes
n.a.
No
No
7
Chappuis et al, 2003
w16
Yes
Yes
Yes
Yes
Yes
Yes
Yes
Yes
Yes
U
Yes
n.a.
No
Yes
11.5
Bern et al, 2000
30
No
No
Yes
U
No
Yes
Yes
Yes
Yes
U
Yes
n.a.
U
No
7.5
Schallig et al, 2002
33
No
Yes
U
U
No
Yes
Yes
Yes
No
U
Yes
n.a.
No
No
6.5
Boelaert et al, 2004
37
Yes
Yes
Yes
Yes
Yes
Yes
U
Yes
Yes
Yes
Yes
n.a.
U
Yes
12
Veeken et al, 2003
38
No
Yes
Yes
Yes
No
Yes
No
No
No
U
U
n.a.
No
No
5
El-Safi et al, 1989
40
No
Yes
U
Yes
No
Yes
Yes
Yes
U
U
Yes
n.a.
No
No
7.5
De Korte et al, 1990
41
No
No
U
Yes
No
Yes
Yes
Yes
No
U
Yes
n.a.
No
No
6
Pal et al, 1991
42
No
Yes
Yes
Yes
No
Yes
Yes
Yes
No
U
Yes
n.a.
No
No
7.5
Sinha et al, 1994
43
No
No
U
U
No
Yes
Yes
Yes
No
U
Yes
n.a.
No
No
5.5
Jha et al, 1996
44
No
Yes
Yes
Yes
No
Yes
No
Yes
No
U
U
n.a.
No
No
6
Joshi et al, 1999
45
No
No
Yes
Yes
No
Yes
Yes
Yes
No
U
Yes
n.a.
No
No
6.5
Boelaert et al, 1999b
46
Yes
Yes
Yes
Yes
Yes
Yes
U
Yes
Yes
U
Yes
n.a.
No
Yes
11
Aoun et al, 2000
47
No
No
Yes
Yes
No
Yes
Yes
No
No
U
Yes
n.a.
No
No
5.5
Alam et al, 1996
48
No
Yes
U
Yes
No
Yes
Yes
No
Yes
U
Yes
n.a.
No
No
7
Bagchi et al, 1998
49
No
No
U
U
No
Yes
Yes
Yes
No
U
Yes
n.a.
No
No
5.5
Meredith et al, 1995
50
No
No
Yes
U
No
Yes
Yes
Yes
No
U
Yes
n.a.
No
No
6
U, unclear; n.a., not assessed
*Reply to items: "yes" = 1; "unclear" = 1/2; "no" or "n.a" = 0; the QUADAS score was obtained by adding up the scores of the 14 items.
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