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Congenital anomalies after treatment for infertility

BMJ 2006; 333 doi: (Published 28 September 2006) Cite this as: BMJ 2006;333:665
  1. Soo-Mi Park, specialist registrar,
  2. Raj Mathur, consultant,
  3. Gordon C S Smith (, professor
  1. Department of Medical Genetics, Addenbrooke's Hospital, Cambridge CB2 2QQ
  2. Department of Reproductive Medicine, Addenbrooke's Hospital
  3. Department of Obstetrics and Gynaecology, Cambridge University, Rosie Hospital, Cambridge CB2 2SW

    Partly related to the cause of infertility

    More than 10 000 children are born each year in the United Kingdom through in vitro fertilisation. Studies have shown an increased risk of adverse outcome in singleton infants conceived by the assisted reproductive technologies of in vitro fertilisation and intracytoplasmic sperm injection. These infants are at increased risk of intrauterine growth retardation, low birth weight, premature delivery, and perinatal mortality compared with infants born to fertile couples.1 A twofold increase in the risk of major congenital malformations has also been reported,24 and there is some evidence of a specific increased risk of imprinting disorders such as Beckwith-Wiedemann and Angelman's syndromes.56 The source of the increased overall risk of anomalies could be the infertility treatment, either from the in vitro procedure or the drugs used to stimulate ovulation, or intrinsic factors associated with infertility itself. Various data have suggested that infertility, especially female infertility, is likely to …

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