Intended for healthcare professionals


More on switching statins: Authors' reply

BMJ 2006; 333 doi: (Published 21 September 2006) Cite this as: BMJ 2006;333:655
  1. James C Moon, specialist registrar (,
  2. Richard G Bogle, acting consultant in cardiology and clinical pharmacology
  1. Department of Cardiology, Heart Hospital, UCL Hospitals NHS Foundation Trust, London W1G 8PH
  2. Experimental Medicine and Toxicology, Imperial College London, London W12 0HS

    EDITOR—Statins all work by blocking the same enzyme but differ in their potency. Higher doses of less potent statins can equal or better lower doses of more potent statins. This is true for simvastatin 40 mg and atorvastatin 10 mg or 20 mg.

    Switching from atorvastatin 10 mg or 20 mg to simvastatin 40 mg represents the largest single drug saving ever available to the NHS. This …

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