Intended for healthcare professionals


Spironolactone and risk of upper gastrointestinal events: Spironolactone may not be guilty

BMJ 2006; 333 doi: (Published 31 August 2006) Cite this as: BMJ 2006;333:500
  1. Eugene Campbell, research fellow (,
  2. Anthony Shonde, research fellow,
  3. Stephen Foley, research fellow
  1. University of Nottingham, Nottingham NG7 2UH

    EDITOR—Verhamme et al present their data and case for warning patients on spironolactone about an increased risk of upper gastrointestinal bleeding.1 They use an electronic database and conditional logistic regression analysis with adjustments. We do …

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