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BMJ 2006; 333 doi: (Published 24 August 2006) Cite this as: BMJ 2006;333:436
  1. Harvey Marcovitch (, BMJ syndication editor

    Diuretics may not provoke gout

    Diuretic treatment is probably not a risk factor for gout, despite the traditional view to the contrary. Investigators in the Netherlands studied 59 general practice patients with a new diagnosis of gout and compared them with three matched controls each. Although the crude incidence rate ratio (IRR) for gout was raised in those taking diuretics, this relation disappeared when adjusted for other common risk factors.

    On multivariate analysis correcting for treatment indication, the IRR for gout in those taking diuretics was 3.9 (95% confidence interval 1.6 to 10) if they were hypertensive and 1.5 (0.5 to 4.1) if they had had a myocardial infarction. The IRR for those in heart failure was 40.1, but confidence intervals were wide and all patients had received …

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