What works in schizophrenia: Depot preparations may improve outcomesBMJ 2006; 333 doi: https://doi.org/10.1136/bmj.333.7563.353 (Published 10 August 2006) Cite this as: BMJ 2006;333:353
- Peter M Haddad, consultant psychiatrist (Peter.Haddad@bstmht.nhs.uk),
- Omair Niaz, specialist registrar in psychiatry
- Sheffield Care Trust, Fulwood House, Sheffield S10 3TG
- Bolton, Salford and Trafford Mental Health NHS Trust, Salford M30 0GT
EDITOR—The study by Tiihonen et al indicates that antipsychotics are not equally effective in treating schizophrenia.1 After a first admission with schizophrenia, patients treated with clozapine, olanzapine, or perphenazine depot had substantially lower risks of readmission, and discontinuation of treatment for any reason, than patients treated with oral haloperidol.
The increased effectiveness of clozapine is understandable in terms of its superior …