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Parathyroid hormone reduces fractures in postmenopausal women with osteoporosis

BMJ 2006; 333 doi: (Published 10 August 2006) Cite this as: BMJ 2006;333:0-e

Research question Is parathyroid hormone a safe and effective treatment for osteoporosis?

Answer Yes. Parathyroid hormone increases bone mineral density, and reduces the risk of fractures in some women

Why did the authors do the study? This systematic review was done to inform the development of a Canadian national guideline on the use of parathyroid hormone to treat osteoporosis. Human parathyroid hormone hPTH 1-34 was licensed in Canada in 2004. The full peptide version hPTH 1-84 is not yet licensed but has been evaluated in randomised controlled trials.

What did they do? They searched systematically through five research databases for all published trials evaluating at least one year of treatment …

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