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Wylie and colleagues have collected valuable data on the increasing
prevalence of MRSA which is adding to the total Staph. aureus burden in
hospitals. We have very little understanding of the reasons for this
phenomenon, to be able to institute effective control measures
Staph. aureus, very much like E.coli, Klebsiella pneumoniae,etc. is
not just a single organism. Numerous genetically diverse clones exist
which vary in their pathogenecity.infectivity, virulence and natural
nidality to a particular environment. Man modifies this environment,
sometimes with disastrous consequences.
MRSA appeared and survived due to the selection pressure from the
heavy use of beta lactam antibiotics. Later the organism evolved probably
by the transduction of mec genes to more successful clones with better
The extensive use of antibiotics is more likely to maintain this
state, unless a new antibiotic which will "search and destroy" MRSA
effectively is introduced. The prospects look gloomy indeed.
No competing interests
11 August 2006
MGR Medical University,Annasalai, Guindy,Chennai, India