Intended for healthcare professionals


Life without COX 2 inhibitors: Risks and benefits are determined by dose and potency

BMJ 2006; 332 doi: (Published 15 June 2006) Cite this as: BMJ 2006;332:1451
  1. Enrique J Sánchez-Delgado, professor (
  1. Hospital Metropolitano Vivian Pellas, Managua, Nicaragua

    EDITOR—The paper by Kearney et al on the risk of atherothrombosis with cyclo-oxygenase-2 (COX 2) inhibitors and traditional non-steroidal anti-inflammatory drugs (NSAIDs) supports the data of Hippisley-Cox et al, who revised the gastrointestinal risks of these drugs.1 2

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    A clear picture is forming, that the risks and benefits are determined by doses and potencies more than by their selectivity to the cyclo-oxygenases, with the exception of low dose aspirin, which permanently inhibits platelet …

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