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It's harder to eradicate Helicobacter pylori in smokers

BMJ 2006; 332 doi: (Published 08 June 2006) Cite this as: BMJ 2006;332:0-e

Research question Does smoking affect treatment for Helicobacter pylori infection?

Answer Yes. Treatment is more likely to fail in smokers than in non-smokers.

Why did the authors do the study? Eradication fails in 10-20% of patients with H pylori infection. There's some evidence that treatment failure is more common among smokers, although the results are not entirely consistent. These authors wanted a more definitive answer, so they searched for all published studies reporting eradication rates among smokers and non-smokers then combined their results.

What did they do? They searched PubMed for all studies published up to August 2005. They included only those reported in English …

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